Communications Biology (Dec 2021)
Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells
- Tomasz M. Grzywa,
- Anna Sosnowska,
- Zuzanna Rydzynska,
- Michal Lazniewski,
- Dariusz Plewczynski,
- Klaudia Klicka,
- Milena Malecka-Gieldowska,
- Anna Rodziewicz-Lurzynska,
- Olga Ciepiela,
- Magdalena Justyniarska,
- Paulina Pomper,
- Marcin M. Grzybowski,
- Roman Blaszczyk,
- Michal Wegrzynowicz,
- Agnieszka Tomaszewska,
- Grzegorz Basak,
- Jakub Golab,
- Dominika Nowis
Affiliations
- Tomasz M. Grzywa
- Department of Immunology, Medical University of Warsaw
- Anna Sosnowska
- Department of Immunology, Medical University of Warsaw
- Zuzanna Rydzynska
- Department of Immunology, Medical University of Warsaw
- Michal Lazniewski
- Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw
- Dariusz Plewczynski
- Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw
- Klaudia Klicka
- Doctoral School of the Medical University of Warsaw
- Milena Malecka-Gieldowska
- Department of Laboratory Medicine, Medical University of Warsaw
- Anna Rodziewicz-Lurzynska
- Central Laboratory, University Clinical Center of Medical University of Warsaw
- Olga Ciepiela
- Department of Laboratory Medicine, Medical University of Warsaw
- Magdalena Justyniarska
- Department of Immunology, Medical University of Warsaw
- Paulina Pomper
- OncoArendi Therapeutics
- Marcin M. Grzybowski
- OncoArendi Therapeutics
- Roman Blaszczyk
- OncoArendi Therapeutics
- Michal Wegrzynowicz
- Laboratory of Molecular Basis of Neurodegeneration, Mossakowski Medical Research Institute, Polish Academy of Sciences
- Agnieszka Tomaszewska
- Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw
- Grzegorz Basak
- Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw
- Jakub Golab
- Department of Immunology, Medical University of Warsaw
- Dominika Nowis
- Department of Immunology, Medical University of Warsaw
- DOI
- https://doi.org/10.1038/s42003-021-02914-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 19
Abstract
Grzywa et al. show that early CD71+ erythroid cells expand in the spleen of anemic mice and in humans and suppress T-cell activation. These results provide insight into the role of CECs in the immune response regulation.
