Nature Communications (Jan 2019)

Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

  • Tiantian Fang,
  • Wanbiao Chen,
  • Yaping Sheng,
  • Siming Yuan,
  • Qiaowei Tang,
  • Gongyu Li,
  • Guangming Huang,
  • Jihu Su,
  • Xuan Zhang,
  • Jianye Zang,
  • Yangzhong Liu

DOI
https://doi.org/10.1038/s41467-018-08102-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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Tetrathiomolybdate (TM) and Cu-ATPases, e.g. Wilson (WLN) protein, affect the efficacy of common anticancer drug cisplatin. Here, the authors show that TM generates a protein dimer with a WLN domain by expelling copper and provide insight into the synergy of TM and cisplatin in cancer chemotherapy.