Nature Communications (Jan 2019)
Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein
Abstract
Tetrathiomolybdate (TM) and Cu-ATPases, e.g. Wilson (WLN) protein, affect the efficacy of common anticancer drug cisplatin. Here, the authors show that TM generates a protein dimer with a WLN domain by expelling copper and provide insight into the synergy of TM and cisplatin in cancer chemotherapy.