Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission

Henning Peter Düsedau; Johannes Steffen; Caio Andreeta Figueiredo; Julia Désirée Boehme; Kristin Schultz; Christian Erck; Martin Korte; Heidi Faber-Zuschratter; Karl-Heinz Smalla; Daniela Dieterich; Andrea Kröger; Dunja Bruder; Ildiko Rita Dunay

doi:10.1128/mBio.01776-21

mBio (Oct 2021)

Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission

Henning Peter Düsedau,
Johannes Steffen,
Caio Andreeta Figueiredo,
Julia Désirée Boehme,
Kristin Schultz,
Christian Erck,
Martin Korte,
Heidi Faber-Zuschratter,
Karl-Heinz Smalla,
Daniela Dieterich,
Andrea Kröger,
Dunja Bruder,
Ildiko Rita Dunay

Affiliations

Henning Peter Düsedau: ORCiD; Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Johannes Steffen: ORCiD; Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Caio Andreeta Figueiredo: ORCiD; Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Julia Désirée Boehme: ORCiD; Institute of Medical Microbiology and Hospital Hygiene, Infection Immunology Group, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Kristin Schultz: Helmholtz Centre for Infection Research, Immune Regulation Group, Braunschweig, Germany
Christian Erck: Helmholtz Centre for Infection Research, Cellular Proteome Research Group, Braunschweig, Germany
Martin Korte: ORCiD; Department of Cellular Neurobiology, Zoological Institute, TU-Braunschweig, Braunschweig, Germany
Heidi Faber-Zuschratter: Leibniz Institute of Neurobiology, Magdeburg, Germany
Karl-Heinz Smalla: ORCiD; Leibniz Institute of Neurobiology, Magdeburg, Germany
Daniela Dieterich: ORCiD; Institute for Pharmacology and Toxicology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Andrea Kröger: ORCiD; Helmholtz Centre for Infection Research, Innate Immunity and Infection Group, Braunschweig, Germany
Dunja Bruder: Institute of Medical Microbiology and Hospital Hygiene, Infection Immunology Group, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany
Ildiko Rita Dunay: ORCiD; Institute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, Magdeburg, Germany

DOI: https://doi.org/10.1128/mBio.01776-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and reoccurring epidemics affecting all age groups. Next to typical disease symptoms, such as fever and fatigue, IAV infection has been associated with behavioral alterations presumably contributing to the development of major depression.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal