Effect of an antiviral and vitamins A, C, D on dopamine and some oxidative stress markers in rat brain exposed to ozone

Abstract

We measured the effect of an antiviral drug and vitamins on dopamine, 5-HIAA and some oxidative biomarkers in the brain of rats exposed to ozone. Groups of Wistar rats received intraperitoneally for 5 days: G1 (control) - 0.9% NaCl; G2 - oseltamivir (an antiviral); G3 - multivitamins (vitamins A, C and D). A similar assay was realized in rats exposed to ozone. The brain was excised and dissected into the cortex, hemispheres, cerebellum and medulla/oblongata to measure the levels dopamine, GSH and lipid peroxidation. Levels of 5-HIAA increased in the cerebellum/medulla oblongata of rats that received vitamins and ozone. Dopamine increased in all regions of the groups that received oseltamivir in the presence of ozone. GSH increased in the hemispheres and cerebellum/medulla oblongata only in groups that received oseltamivir and ozone. We found that vitamins and oseltamivir altered serotonin metabolism in the brains of young rats. Oxidative stress may be involved in these effects.

Keywords

• Dopamine
• lipid peroxidation
• oseltamivir
• ozone
• vitamins