Nature Communications (Mar 2021)

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice

  • Sangsu Bang,
  • Christopher R. Donnelly,
  • Xin Luo,
  • Maria Toro-Moreno,
  • Xueshu Tao,
  • Zilong Wang,
  • Sharat Chandra,
  • Andrey V. Bortsov,
  • Emily R. Derbyshire,
  • Ru-Rong Ji

DOI
https://doi.org/10.1038/s41467-021-21940-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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GPR37 is expressed in macrophages, and has been implicated in resolution of inflammatory pain. Here the authors show that GPR37 can modulate sepsis in several animal models.