Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

David A. Rollins; Joubert B. Kharlyngdoh; Maddalena Coppo; Bowranigan Tharmalingam; Sanda Mimouna; Ziyi Guo; Maria A. Sacta; Miles A. Pufall; Robert P. Fisher; Xiaoyu Hu; Yurii Chinenov; Inez Rogatsky

doi:10.1038/s41467-017-01569-2

Nature Communications (Nov 2017)

Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

David A. Rollins,
Joubert B. Kharlyngdoh,
Maddalena Coppo,
Bowranigan Tharmalingam,
Sanda Mimouna,
Ziyi Guo,
Maria A. Sacta,
Miles A. Pufall,
Robert P. Fisher,
Xiaoyu Hu,
Yurii Chinenov,
Inez Rogatsky

Affiliations

David A. Rollins: Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences
Joubert B. Kharlyngdoh: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Maddalena Coppo: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Bowranigan Tharmalingam: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Sanda Mimouna: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Ziyi Guo: Institute for Immunology and School of Medicine, Tsinghua University
Maria A. Sacta: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Miles A. Pufall: Department of Biochemistry, University of Iowa
Robert P. Fisher: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Xiaoyu Hu: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Yurii Chinenov: Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center
Inez Rogatsky: Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences

DOI: https://doi.org/10.1038/s41467-017-01569-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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