Meta-Analysis of the association of IGF2BP2 gene rs4402960 polymorphisms with T2DM in Asia

Abstract

In order to evaluate the association of IGF2BP2 (SNPS:rs4402960) gene polymorphism and type 2 diabetes mellitus (T2DM) susceptibility, we searched for all the related research literature by CNKI, Wanfan, Pubmed and Springer link database to collect data.Meta-analysis software(RevMan5.0) was applied for heterogeneity tests in genotype level, two methods(fixed-effects and random-effects model)were performed to pool the odds ratio(OR). Random-effects model was adopted if there were obvious heterogeneity among studies. On the contrary, a fixed effect model was used. At the same time, publication bias was examined by Funnel plot. The studies collected 28 articles(including 35 studies), and included 52277cases of T2DM and 54168 controls. The pooled ORs of allele (T vs G)of rs4402960 polymorphic loci in IGF2BP2 was significant association with T2DM (OR=1.163 95%CI=[1.138,1.189] P<0.00001).