A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones

Abstract

A new synthetic route initiated with Groebke–Blackburn–Bienaymé (GBB) followed by N-acylation, intramolecular Diels–Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the substitution groups for the IMDA reaction is performed to understand the reaction mechanism.

Keywords

• groebke–blackburn–bienaymé (gbb)
• imidazopyridine
• intramolecular diels–alder (imda)
• isoquinolinone
• multicomponent reaction (mcr)
• re-aromatization