The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats

Abstract

Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β (Aβ)-induced neurogenesis deficits in rats. Methods: Adult Wistar male rats in the current study were treated with intrahippocampal Aβ as well as intraperitoneal callistephin injection. The day after the last administration, neuroD expression was assessed using an immunohistochemistry method. Finally, data were analyzed with SPSS using the one-way ANOVA test. Results: Results of the current study showed that Aβ significantly decreased the expression of neuroD and callistephin could attenuate these changes. Conclusion: In conclusion, results of the study suggested that callistephin can improve Aβ-induced neurogenesis changes in rats.

Keywords

• alzheimer's disease
• neurogenesis
• anthocyanins