Emerging Microbes and Infections (Dec 2024)
Invasive pneumococcal diseases in Chinese children: a multicentre hospital-based active surveillance from 2019 to 2021
- Xue Ning,
- Lianmei Li,
- Jing Liu,
- Fang Wang,
- Kun Tan,
- Wenhui Li,
- Kai Zhou,
- Shujun Jing,
- Aiwei Lin,
- Jing Bi,
- Shiyong Zhao,
- Huiling Deng,
- Chunhui Zhu,
- Shanshan Lv,
- Juan Li,
- Jun Liang,
- Qing Zhao,
- Yumin Wang,
- Biquan Chen,
- Liang Zhu,
- Guowu Shen,
- Jianlong Liu,
- Zhi Li,
- Jikui Deng,
- Xin Zhao,
- Mingfeng Shan,
- Yi Wang,
- Shihua Liu,
- Tingting Jiang,
- Xuexia Chen,
- Yufeng Zhang,
- Sha Cai,
- Lixue Wang,
- Xudong Lu,
- Jinghui Jiang,
- Fang Dong,
- Lan Ye,
- Jing Sun,
- Kaihu Yao,
- Yonghong Yang,
- Gang Liu
Affiliations
- Xue Ning
- Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, People’s Republic of China
- Lianmei Li
- Department of Infectious and Digestive Diseases, Qinghai Province Women and Children's Hospital, Xining, People’s Republic of China
- Jing Liu
- Department of Infectious Diseases, Hunan Children’s Hospital, Changsha, People’s Republic of China
- Fang Wang
- Department of Infectious Diseases, Henan Children’s Hospital, (Children's Hospital Affiliated of Zhengzhou University, Zhengzhou Children's Hospital), Zhengzhou, People’s Republic of China
- Kun Tan
- Department of Infectious Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China
- Wenhui Li
- Department of Infectious and Digestive Diseases, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China
- Kai Zhou
- Department of Infectious Diseases, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China
- Shujun Jing
- Department of Infectious Diseases, Dalian Children’s Hospital, Dalian, People’s Republic of China
- Aiwei Lin
- Department of Infectious Diseases, Children’s Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
- Jing Bi
- Department of Infectious Diseases, Baoding Children’s Hospital, Baoding, People’s Republic of China
- Shiyong Zhao
- Department of Infectious Diseases, Hangzhou Children’s Hospital, Hangzhou, People’s Republic of China
- Huiling Deng
- Department of Infectious Diseases, Xian Children’s Hospital, Xian, People’s Republic of China
- Chunhui Zhu
- Department of Infectious Diseases, Children’s Hospital of Jiangxi Province, Nanchang, People’s Republic of China
- Shanshan Lv
- Department of Infectious Diseases, Changchun Children’s Hospital, Changchun, People’s Republic of China
- Juan Li
- Department of Infectious Diseases, Urumqi Children’s Hospital, Urumqi, People’s Republic of China
- Jun Liang
- Department of Pediatric Intensive Care Unit, People’s Hospital of Liaocheng, Liaocheng, People’s Republic of China
- Qing Zhao
- Department of Infectious Diseases, Children’s Hospital of Shanxi Province, Taiyuan, People’s Republic of China
- Yumin Wang
- Department of Infectious Diseases, Maternal and Child Health Care Hospital of the Inner Mongolia autonomous region, Huhehaote, People’s Republic of China
- Biquan Chen
- Department of Infectious Diseases, Anhui Provincial Children’s Hospital, Hefei, People’s Republic of China
- Liang Zhu
- Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, People’s Republic of China
- Guowu Shen
- Department of clinical laboratory, Qinghai Province Women and Children's Hospital, Xining, People’s Republic of China
- Jianlong Liu
- Department of clinic laboratory, Hunan Children’s Hospital, Changsha, People’s Republic of China
- Zhi Li
- Department of Infectious Diseases, Henan Children’s Hospital, (Children's Hospital Affiliated of Zhengzhou University, Zhengzhou Children's Hospital), Zhengzhou, People’s Republic of China
- Jikui Deng
- Department of Infectious Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China
- Xin Zhao
- Department of Infectious and Digestive Diseases, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China
- Mingfeng Shan
- Department of Infectious Diseases, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China
- Yi Wang
- Department of Infectious Diseases, Dalian Children’s Hospital, Dalian, People’s Republic of China
- Shihua Liu
- Department of Infectious Diseases, Children’s Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
- Tingting Jiang
- Department of Infectious Diseases, Baoding Children’s Hospital, Baoding, People’s Republic of China
- Xuexia Chen
- Department of Infectious Diseases, Hangzhou Children’s Hospital, Hangzhou, People’s Republic of China
- Yufeng Zhang
- Department of Infectious Diseases, Xian Children’s Hospital, Xian, People’s Republic of China
- Sha Cai
- Department of Infectious Diseases, Children’s Hospital of Jiangxi Province, Nanchang, People’s Republic of China
- Lixue Wang
- Department of Infectious Diseases, Changchun Children’s Hospital, Changchun, People’s Republic of China
- Xudong Lu
- Department of Infectious Diseases, Urumqi Children’s Hospital, Urumqi, People’s Republic of China
- Jinghui Jiang
- Department of Pediatric Intensive Care Unit, People’s Hospital of Liaocheng, Liaocheng, People’s Republic of China
- Fang Dong
- Department of Infectious Diseases, Children’s Hospital of Shanxi Province, Taiyuan, People’s Republic of China
- Lan Ye
- Department of Infectious Diseases, Maternal and Child Health Care Hospital of the Inner Mongolia autonomous region, Huhehaote, People’s Republic of China
- Jing Sun
- Department of Infectious Diseases, Anhui Provincial Children’s Hospital, Hefei, People’s Republic of China
- Kaihu Yao
- Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, Beijing, People’s Republic of China
- Yonghong Yang
- Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, Beijing, People’s Republic of China
- Gang Liu
- Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, People’s Republic of China
- DOI
- https://doi.org/10.1080/22221751.2024.2332670
- Journal volume & issue
-
Vol. 13,
no. 1
Abstract
ABSTRACTThis study aimed to provide data for the clinical features of invasive pneumococcal disease (IPD) and the molecular characteristics of Streptococcus pneumoniae isolates from paediatric patients in China. We conducted a multi-centre prospective study for IPD in 19 hospitals across China from January 2019 to December 2021. Data of demographic characteristics, risk factors for IPD, death, and disability was collected and analysed. Serotypes, antibiotic susceptibility, and multi-locus sequence typing (MLST) of pneumococcal isolates were also detected. A total of 478 IPD cases and 355 pneumococcal isolates were enrolled. Among the patients, 260 were male, and the median age was 35 months (interquartile range, 12–46 months). Septicaemia (37.7%), meningitis (32.4%), and pneumonia (27.8%) were common disease types, and 46 (9.6%) patients died from IPD. Thirty-four serotypes were detected, 19F (24.2%), 14 (17.7%), 23F (14.9%), 6B (10.4%) and 19A (9.6%) were common serotypes. Pneumococcal isolates were highly resistant to macrolides (98.3%), tetracycline (94.1%), and trimethoprim/sulfamethoxazole (70.7%). Non-sensitive rates of penicillin were 6.2% and 83.3% in non-meningitis and meningitis isolates. 19F-ST271, 19A-ST320 and 14-ST876 showed high resistance to antibiotics. This multi-centre study reports the clinical features of IPD and demonstrates serotype distribution and antibiotic resistance of pneumococcal isolates in Chinese children. There exists the potential to reduce IPD by improved uptake of pneumococcal vaccination, and continued surveillance is warranted.
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