Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance

Yan-Ting Chen; Qi-Yuan Yang; Yun Hu; Xiang-Dong Liu; Jeanene M. de Avila; Mei-Jun Zhu; Peter W. Nathanielsz; Min Du

doi:10.1038/s41467-021-27171-1

Nature Communications (Nov 2021)

Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance

Yan-Ting Chen,
Qi-Yuan Yang,
Yun Hu,
Xiang-Dong Liu,
Jeanene M. de Avila,
Mei-Jun Zhu,
Peter W. Nathanielsz,
Min Du

Affiliations

Yan-Ting Chen: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University
Qi-Yuan Yang: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University
Yun Hu: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University
Xiang-Dong Liu: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University
Jeanene M. de Avila: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University
Mei-Jun Zhu: School of Food Sciences, Washington State University
Peter W. Nathanielsz: Wyoming Pregnancy and Life Course Health Center, Department of Animal Science, University of Wyoming
Min Du: Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University

DOI: https://doi.org/10.1038/s41467-021-27171-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Maternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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