St18 specifies globus pallidus projection neuron identity in MGE lineage

Luke F. Nunnelly; Melissa Campbell; Dylan I. Lee; Patrick Dummer; Guoqiang Gu; Vilas Menon; Edmund Au

doi:10.1038/s41467-022-35518-5

Nature Communications (Dec 2022)

St18 specifies globus pallidus projection neuron identity in MGE lineage

Luke F. Nunnelly,
Melissa Campbell,
Dylan I. Lee,
Patrick Dummer,
Guoqiang Gu,
Vilas Menon,
Edmund Au

Affiliations

Luke F. Nunnelly: Department of Pathology & Cell Biology, Columbia University Irving Medical Center
Melissa Campbell: Department of Pathology & Cell Biology, Columbia University Irving Medical Center
Dylan I. Lee: Department of Neurology, Columbia University Irving Medical Center
Patrick Dummer: Department of Pathology & Cell Biology, Columbia University Irving Medical Center
Guoqiang Gu: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine
Vilas Menon: Department of Neurology, Columbia University Irving Medical Center
Edmund Au: Department of Pathology & Cell Biology, Columbia University Irving Medical Center

DOI: https://doi.org/10.1038/s41467-022-35518-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The medial ganglionic eminence produces both interneurons and projection neurons, though how this fate choice is made is not well established. Here they show that St18 regulates migration and morphology of MGE neurons, inducing projection neuron fates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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