Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Abstract

Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus. An acute toxicity has been investigated for 11 eleven different classes of synthesized compounds based on heterocyclic triazole system. Methods. Investigations have been carried out using white Wistar rats. Five groups of animals have been used to determine LD50 of 5-R-1,2,4-triazole-3-thiones and its derivatives. Two observations have been set for each group using a previous dose and the next one. Conclusion. The obtained results show that LD50values of new 1,2,4-triazole-3-thiones derivatives which contain methoxyphenyl substituents in 5th position of the triazole nucleus, are in rage 304±65-1245±197 mg/kg. Investigated compounds are low-toxic or non-toxic substances according to Sidorov classification. The presence and nature of substituents at the 1,2,4-triazole nucleus and nature of substituents connected with Sulfur in third position of 1,2,4-triazole nucleus affect the acute toxicity of 5-R-1,2,4-triazole-3-thiones and its derivatives.

Keywords

• 1 2 4-triazoles
• Acute Toxicity Tests