Nature Communications (Dec 2019)

The Escherichia coli transcriptome mostly consists of independently regulated modules

  • Anand V. Sastry,
  • Ye Gao,
  • Richard Szubin,
  • Ying Hefner,
  • Sibei Xu,
  • Donghyuk Kim,
  • Kumari Sonal Choudhary,
  • Laurence Yang,
  • Zachary A. King,
  • Bernhard O. Palsson

DOI
https://doi.org/10.1038/s41467-019-13483-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specific transcriptional regulators.