Association between KRAS Gene rs61764370 Polymorphism and Risk of developing Hashimoto\'s Thyroiditis

Abstract

Background and Aim: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease, characterised by the destruction of the thyroid gland due to the production of autoantibodies against thyroid peroxidase and thyroglobulin. Studies have shown the interaction between some genetic changes in the cell and environmental factors as one of the risk factors for the occurrence of HT. The aim of the present study was to investigate the relationship between the rs61764370 polymorphism in the KRAS gene and the risk of development of HT. Materials and Methods: 120 HT patients and 120 healthy controls who had been matched in regard to age and gender participated in this study. PCR-RFLP method was used to determine the genotypes. Results: The frequency rates of AA, AC and CC genotypes were 87.5%, 8.5% and 6.7% in the control group, and 93.3%, 5.3% and 0.8% in the patient group respectively. Our results showed that the frequency of CC genotype was significantly higher in the control group than that in the patient group (P≤0.05). Conclusion: Our results suggested the protective effect of the CC genotype and C allele of the rs61764370 polymorphism in the KRAS gene on the development of HT.

Keywords

• hashimoto's thyroiditis
• kras
• polymorphism
• zahedan