E-Journal of Chemistry (Jan 2012)

Versatile Microwave-Assisted and Lanthanum Chloride Catalysed Synthesis of Polysubstituted Imidazoles Using Urea/Thiourea as Benign Source of Ammonia

  • Mohammad Reza Manafi,
  • Pedram Manafi,
  • Mohammad Reza Kalaee

DOI
https://doi.org/10.1155/2012/396127
Journal volume & issue
Vol. 9, no. 4
pp. 1773 – 1777

Abstract

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Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification.