The data provided here related to our research article (Chen et al., 2016) [1]. We provide whole-brain intrinsic functional connectivity patterns in obsessive–compulsive disorder at resting-state [1]. This article also provides supplementary information to our research article, i.e., between – group comparisons of the effect of selective serotonin reuptake inhibitors (SSRIs) and combined depression symptoms on resting-state neural activities in obsessive–compulsive disorder. The data presented here provide novel insights into the effect of SSRIs and combined depression symptoms on the neural activities at rest. Keywords: Obsessive-compulsive disorder, Selective serotonin reuptake inhibitors (SSRIs), Depression, Regional homogeneity, Functional connectivity