Nature Communications (Apr 2022)

DNA sequence-dependent formation of heterochromatin nanodomains

  • Graeme J. Thorn,
  • Christopher T. Clarkson,
  • Anne Rademacher,
  • Hulkar Mamayusupova,
  • Gunnar Schotta,
  • Karsten Rippe,
  • Vladimir B. Teif

DOI
https://doi.org/10.1038/s41467-022-29360-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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The ability to predict epigenetic regulation is an important challenge in biology. Here the authors describe heterochromatin nanodomains (HNDs) and compare four different types of H3K9me2/3-marked HNDs in mouse embryonic stem cells. They further develop a computational framework to predict genome-wide HND maps from DNA sequence and protein concentrations, at single-nucleotide resolution.