Aspirin resistance: clinical and molecular genetic evaluation techniques

Abstract

The article discusses the issues related to the personalization of preventive measures for ischemic stroke, in particular those associated with resistance to one of the most common antiplatelet drugs, aspirin. A brief historical note on investigation of acetylsalicylic acid is provided. The paper addresses the issue of etiological factors and epidemiology of aspirin resistance. Ananalysis and comparison of various techniques for evaluation ofthis phenomenon are performed. Separately, a molecular genetic aspect of the pathology is considered. In conclusion, the recommendations for overcoming tolerance to aspirin therapy are provided.

Keywords

• stroke prevention
• aspirin resistance
• platelet aggregation
• cerebrovascular pathology