Nature Communications (Mar 2023)
Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress
- Haibo Wang,
- Ligang Hu,
- Hongyan Li,
- Yau-Tsz Lai,
- Xueying Wei,
- Xiaohan Xu,
- Zhenkun Cao,
- Huiming Cao,
- Qianya Wan,
- Yuen-Yan Chang,
- Aimin Xu,
- Qunfang Zhou,
- Guibin Jiang,
- Ming-Liang He,
- Hongzhe Sun
Affiliations
- Haibo Wang
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Ligang Hu
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Hongyan Li
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Yau-Tsz Lai
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Xueying Wei
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Xiaohan Xu
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Zhenkun Cao
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Huiming Cao
- Institute of Environment and Health, Jianghan University
- Qianya Wan
- Department of Biomedical Science, City University of Hong Kong
- Yuen-Yan Chang
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- Aimin Xu
- Department of Pharmacology and Pharmacy, and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Qunfang Zhou
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
- Guibin Jiang
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
- Ming-Liang He
- Department of Biomedical Science, City University of Hong Kong
- Hongzhe Sun
- Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-023-37351-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Despite common use as a diabetes mellitus supplement, chromium(III)’s pharmacological effects remain unknown. We identified the Cr(III)-proteome in cells with a metalloproteomic approach and uncovered ATP synthase as a vital target to relieve hyperglycaemia stress.
