Multi-Response Optimization in the Formulation of a Topical Cream from Natural Ingredients

Gertrude Eleonore DJIOBIE TCHIENOU; Roli Karole TSATSOP TSAGUE; Therese Florence MBAM PEGA; Vera BAMA; Albert BAMSECK; Selestin DONGMO SOKENG; Martin Benoît NGASSOUM

doi:10.3390/cosmetics5010007

Cosmetics (Jan 2018)

Multi-Response Optimization in the Formulation of a Topical Cream from Natural Ingredients

Gertrude Eleonore DJIOBIE TCHIENOU,
Roli Karole TSATSOP TSAGUE,
Therese Florence MBAM PEGA,
Vera BAMA,
Albert BAMSECK,
Selestin DONGMO SOKENG,
Martin Benoît NGASSOUM

Affiliations

Gertrude Eleonore DJIOBIE TCHIENOU: Department of Applied Chemistry, National School of Agro-Industrial Sciences, University of Ngaoundere, P.O. Box 455 Ngaoundere, Cameroon
Roli Karole TSATSOP TSAGUE: Department of Applied Chemistry, National School of Agro-Industrial Sciences, University of Ngaoundere, P.O. Box 455 Ngaoundere, Cameroon
Therese Florence MBAM PEGA: Department of Applied Chemistry, National School of Agro-Industrial Sciences, University of Ngaoundere, P.O. Box 455 Ngaoundere, Cameroon
Vera BAMA: Department of Applied Chemistry, National School of Agro-Industrial Sciences, University of Ngaoundere, P.O. Box 455 Ngaoundere, Cameroon
Albert BAMSECK: Department of Biological Sciences, Faculty of Sciences, Ngaoundere University, P.O. Box 454 Ngaoundere, Cameroon
Selestin DONGMO SOKENG: Department of Biological Sciences, Faculty of Sciences, Ngaoundere University, P.O. Box 454 Ngaoundere, Cameroon
Martin Benoît NGASSOUM: Department of Applied Chemistry, National School of Agro-Industrial Sciences, University of Ngaoundere, P.O. Box 455 Ngaoundere, Cameroon

DOI: https://doi.org/10.3390/cosmetics5010007
Journal volume & issue: Vol. 5, no. 1
p. 7

Abstract

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The aim of this research was to study the effect of local raw materials on the formulation of a base cream formulation and determine the optimum proportion of each material that gives the required properties. Physicochemical properties of cream formulations can be affected by their viscosity, spreadability, and particle size. The quality of the base cream is directly linked to the basic material used in the formulation. Screening of independent factors, namely oil phase (sesame oil, soybean oil, and liquid paraffin), aqueous phase (Aloe vera gel, propylene glycol, and glycerol), and surfactant (soy lecithin, tween, and soy lecithin/tween) was done to choose the best raw material required for the preparation of the base cream. Based on the screening criteria, sesame oil, Aloe vera gel, and soy lecithin were chosen as the best local raw materials. Using a multi-response optimization, the mixing fractions of sesame oil, Aloe vera gel, and soy lecithin were found to be 24%, 28%, and 10%, respectively. This base cream can be used as a suitable matrix for formulation in the cosmetic and pharmaceutical industries.

Published in Cosmetics

ISSN: 2079-9284 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://www.mdpi.com/journal/cosmetics

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