Clinical and Experimental Dental Research (Feb 2022)

Stability of biomaterials used in adjunct to coronally advanced flap: A systematic review and network meta‐analysis

  • Sourav Panda,
  • Shahnawaz Khijmatgar,
  • Heber Arbildo‐Vega,
  • Abhaya Chandra Das,
  • Manoj Kumar,
  • Mohit Das,
  • Leonardo Mancini,
  • Massimo Del Fabbro

DOI
https://doi.org/10.1002/cre2.461
Journal volume & issue
Vol. 8, no. 1
pp. 421 – 438

Abstract

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Abstract Aim The objective of this network meta‐analysis was to rank different biomaterials used in adjunct to coronally advanced flap (CAF), based on their performance in root‐coverage for Miller's Class I and II gingival recessions. Materials and methods An electronic database search was carried out in PUBMED, CENTRAL, SCOPUS, and EMBASE to identify the eligible articles and compiled into the citation manager to remove the duplicates. The primary outcome was keratinized gingival tissue width (KGW) and percentage of root coverage (%RC). The treatment effect of different biomaterials was estimated using predictive interval plots and ranked based on biomaterials performance, using multidimensional scale ranking. Results CAF + connective tissue graft (CTG), CAF + platelet concentrate matrix (PCM) and acellular dermal matrix (ADM) ranked at the top positions in performance in improving KGW. The highest ranked materials in improving percentage of root coverage in gingival recession were CAF + collagen matrix (CM) + gingival fibroblasts (GF), CAF + ADM + platelet rich plasma (PRP) and CAF + ADM, as compared to CAF alone. Conclusion CTG, ADM, platelet concentrates, and CM + GFs, when used in adjunct to CAF, showed improved stability over ≥12 months of follow‐up, better percentage of root coverage, and improved keratinized gingival width.

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