Nature Communications (Dec 2021)

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

  • Yuxian Guo,
  • Yaru Liu,
  • Shihao Zhao,
  • Wangting Xu,
  • Yiqing Li,
  • Pengwei Zhao,
  • Di Wang,
  • Hongqiang Cheng,
  • Yuehai Ke,
  • Xue Zhang

DOI
https://doi.org/10.1038/s41467-021-27428-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Redox-dependent regulation plays a key role in the pathogenesis of acute lung injury, but its mechanism is unclear. Here the authors show Grx1-regulated S-glutathionylation of FABP5 controls macrophage inflammation and alleviates acute lung injury.