Phosphoregulated orthogonal signal transduction in mammalian cells

Leo Scheller; Marc Schmollack; Adrian Bertschi; Maysam Mansouri; Pratik Saxena; Martin Fussenegger

doi:10.1038/s41467-020-16895-1

Nature Communications (Jun 2020)

Phosphoregulated orthogonal signal transduction in mammalian cells

Leo Scheller,
Marc Schmollack,
Adrian Bertschi,
Maysam Mansouri,
Pratik Saxena,
Martin Fussenegger

Affiliations

Leo Scheller: Department of Biosystems Science and Engineering, ETH Zurich
Marc Schmollack: Department of Biosystems Science and Engineering, ETH Zurich
Adrian Bertschi: Department of Biosystems Science and Engineering, ETH Zurich
Maysam Mansouri: Department of Biosystems Science and Engineering, ETH Zurich
Pratik Saxena: Department of Biosystems Science and Engineering, ETH Zurich
Martin Fussenegger: Department of Biosystems Science and Engineering, ETH Zurich

DOI: https://doi.org/10.1038/s41467-020-16895-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Phosphoregulation is a key mechanism of signal processing. Here the authors build a phosphoregulated relay system in mammalian cells for orthogonal signal transduction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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