Cell Therapy in Idiopathic Pulmonary Fibrosis†

Abstract

Idiopathic pulmonary fibrosis is a fatal disease with no effective or curative treatment options. In recent decades, cell-based therapies using stem cells or lung progenitor cells to regenerate lung tissue have experienced rapid growth in both preclinical animal models and translational clinical studies. In this review, the current knowledge of these cell therapies is summarized. Although further investigations are required, these studies indicate that cell therapies are a promising therapeutic approach for the treatment of idiopathic pulmonary fibrosis.

Keywords

• cell therapy
• stem cells
• lung progenitor cells
• preclinical studies
• bleomycin
• pulmonary fibrosis
• clinical studies
• idiopathic pulmonary fibrosis