Nature Communications (Mar 2023)
Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
- Veronica Veschi,
- Alice Turdo,
- Chiara Modica,
- Francesco Verona,
- Simone Di Franco,
- Miriam Gaggianesi,
- Elena Tirrò,
- Sebastiano Di Bella,
- Melania Lo Iacono,
- Vincenzo Davide Pantina,
- Gaetana Porcelli,
- Laura Rosa Mangiapane,
- Paola Bianca,
- Aroldo Rizzo,
- Elisabetta Sciacca,
- Irene Pillitteri,
- Veronica Vella,
- Antonino Belfiore,
- Maria Rita Bongiorno,
- Giuseppe Pistone,
- Lorenzo Memeo,
- Lorenzo Colarossi,
- Dario Giuffrida,
- Cristina Colarossi,
- Paolo Vigneri,
- Matilde Todaro,
- Giorgio Stassi
Affiliations
- Veronica Veschi
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Alice Turdo
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Chiara Modica
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Francesco Verona
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Simone Di Franco
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Miriam Gaggianesi
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Elena Tirrò
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Sebastiano Di Bella
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Melania Lo Iacono
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Vincenzo Davide Pantina
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- Gaetana Porcelli
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Laura Rosa Mangiapane
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Paola Bianca
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Aroldo Rizzo
- Villa Sofia-Cervello Hospital
- Elisabetta Sciacca
- Queen Mary University, Experimental Medicine & Rheumatology
- Irene Pillitteri
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Veronica Vella
- Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital
- Antonino Belfiore
- Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital
- Maria Rita Bongiorno
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Giuseppe Pistone
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Lorenzo Memeo
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Lorenzo Colarossi
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Dario Giuffrida
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Cristina Colarossi
- Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande
- Paolo Vigneri
- Department of Clinical and Experimental Medicine, A.O.U. Policlinico-Vittorio Emanuele, Center of Experimental Oncology and Hematology, University of Catania
- Matilde Todaro
- Department of Health Promotion Sciences, Internal Medicine and Medical Specialties, University of Palermo
- Giorgio Stassi
- Department of Surgical Oncological and Stomatological Sciences, University of Palermo
- DOI
- https://doi.org/10.1038/s41467-023-36922-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. Here, the authors show the ability of human embryonic stem cells (hESCs) to recapitulate the different TC histotypes upon specific genomic alterations delivered by CRISPR-Cas9 and identify KISS1R and TIMP1 targeting as a therapeutic adjuvant option for undifferentiated TCs.
