Case Reports in Gastroenterology (May 2016)

Pancreatic Acinar Cell Carcinoma

  • Dominique Béchade,
  • Marie Desjardin,
  • Emma Salmon,
  • Grégoire Désolneux,
  • Yves Bécouarn,
  • Serge Evrard,
  • Marianne Fonck

DOI
https://doi.org/10.1159/000445867
Journal volume & issue
Vol. 10, no. 1
pp. 174 – 180

Abstract

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Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1–2% of all pancreatic neoplasms. Here we report two cases of ACC and describe their clinical features, the therapies used to treat them, and their prognosis. The first patient was a 65-year-old woman who had an abdominal CT scan for a urinary infection. Fortuitously, a rounded and well-delimited corporeal pancreatic tumor was discovered. An endoscopic ultrasound (EUS)-guided fine needle aspiration revealed an ACC. During the puncture, a hypoechoic cavity appeared inside the lesion, corresponding to a probable necrotic area. Treatment consisted of a distal splenopancreatectomy. The second patient was a 75-year-old man who complained of abdominal pain. An abdominal CT scan showed a cephalic pancreatic lesion and two hepatic metastases. An EUS-guided fine needle aspiration showed a pancreatic ACC. The patient received chemotherapy with gemcitabine plus oxaliplatin (GEMOX regimen), which enabled an objective response after 6 cycles.

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