The COVID-19 pandemic, caused by SARS-CoV-2, disrupted work and life patterns worldwide, underscoring the urgency of addressing climate change. Despite contributing minimally to global greenhouse gas (GHG) emissions, Africa faces disproportionate vulnerability to the impacts of climate change. This commentary explores the benefits of blended work models (remote and in-office work) and the readiness of African cities to adopt them. Notably, the shift to working from home (WFH) during the pandemic improved individual well-being and reduced office energy consumption and commuting-related emissions. Robust digital infrastructure and organizational and sustainable policies are essential to fully leverage blended work for urban sustainability. The unexpected opportunities that arose during the pandemic could help African cities address climate change through careful planning and investment.