Hippocampal Metabolite Alterations in Long-term Insulin-treated Type 1 Diabetes Mellitus Rats Revealed by 1H MRS

XU Hui; WU Yi-ting; WANG Xu-xia; KANG Yan; LEI Hao; GAO Li-feng

doi:10.11938/cjmr20212955

Chinese Journal of Magnetic Resonance (Dec 2022)

Hippocampal Metabolite Alterations in Long-term Insulin-treated Type 1 Diabetes Mellitus Rats Revealed by 1H MRS

XU Hui,
WU Yi-ting,
WANG Xu-xia,
KANG Yan,
LEI Hao,
GAO Li-feng

Affiliations

XU Hui: 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan (Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences), Wuhan 430071, China 2. University of Chinese Academy of Sciences, Beijing 100049, China
WU Yi-ting: Department of Medical Imaging, School of Medicine, Jianghan University, Wuhan 430056, China
WANG Xu-xia: 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan (Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences), Wuhan 430071, China 2. University of Chinese Academy of Sciences, Beijing 100049, China
KANG Yan: 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan (Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences), Wuhan 430071, China 2. University of Chinese Academy of Sciences, Beijing 100049, China
LEI Hao: 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan (Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences), Wuhan 430071, China 2. University of Chinese Academy of Sciences, Beijing 100049, China
GAO Li-feng: Department of Medical Imaging, School of Medicine, Jianghan University, Wuhan 430056, China

DOI: https://doi.org/10.11938/cjmr20212955
Journal volume & issue: Vol. 39, no. 04
pp. 393 – 400

Abstract

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In this study, 1H magnetic resonance spectroscopy (1H MRS) was used to analyze metabolites in the hippocampus of chronic type 1 diabetes mellitus (T1DM) rats induced by streptozocin and T1DM rats treated with long-term insulin. The results showed that, compared with control rats and insulin-treated T1DM rats, the fasting blood glucose of T1DM rats increased significantly, while the body weight of T1DM rats decreased remarkably (p < 0.05). The contents of myo-inositol (Ins), taurine (Tau) and glutamate (Glu) of T1DM rats were significantly higher than those of control rats (p=0.000, p=0.003, p=0.014, respectively), and the contents of Ins and Tau of insulin-treated T1DM rats were significantly decreased than those in the T1DM diabetic rats (p=0.000, p=0.010, respectively). Contents of Glu and Glx (Glu and glutamine) of insulin-treated T1DM rats were significantly higher than those in the control group (p=0.007, p=0.042, respectively). The metabolite changes of Ins and Tau in hippocampus of T1DM rats are sensitive to insulin treatment.

Published in Chinese Journal of Magnetic Resonance

ISSN: 1000-4556 (Print)
Publisher: Science Press
Country of publisher: China
LCC subjects: Science: Physics: Electricity and magnetism
Website: http://121.43.60.238/bpxzz/EN/1000-4556/home.shtml

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