BMC Research Notes (Oct 2018)
Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study
- Maja Kopczynska,
- Ben Sharif,
- Sian Cleaver,
- Naomi Spencer,
- Amit Kurani,
- Camilla Lee,
- Jessica Davis,
- Carys Durie,
- Jude Joseph-Gubral,
- Angelica Sharma,
- Lucy Allen,
- Billie Atkins,
- Alex Gordon,
- Llewelyn Jones,
- Amy Noble,
- Matthew Bradley,
- Henry Atkinson,
- Joy Inns,
- Harriet Penney,
- Carys Gilbert,
- Rebecca Walford,
- Louise Pike,
- Ross Edwards,
- Robyn Howcroft,
- Hazel Preston,
- Jennifer Gee,
- Nicholas Doyle,
- Charlotte Maden,
- Claire Smith,
- Nik Syakirah Nik Azis,
- Navrhinaa Vadivale,
- Tamas Szakmany,
- Welsh Digital Data Collection Platform Collaborators
Affiliations
- Maja Kopczynska
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Ben Sharif
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Sian Cleaver
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Naomi Spencer
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Amit Kurani
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Camilla Lee
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Jessica Davis
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Carys Durie
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Jude Joseph-Gubral
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Angelica Sharma
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Lucy Allen
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Billie Atkins
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Alex Gordon
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Llewelyn Jones
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Amy Noble
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Matthew Bradley
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Henry Atkinson
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Joy Inns
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Harriet Penney
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Carys Gilbert
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Rebecca Walford
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Louise Pike
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Ross Edwards
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Robyn Howcroft
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Hazel Preston
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Jennifer Gee
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Nicholas Doyle
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Charlotte Maden
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Claire Smith
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Nik Syakirah Nik Azis
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Navrhinaa Vadivale
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Tamas Szakmany
- Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University
- Welsh Digital Data Collection Platform Collaborators
- DOI
- https://doi.org/10.1186/s13104-018-3819-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 6
Abstract
Abstract Objective Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. Results 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%).
Keywords
