Nature Communications (Sep 2017)

MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

  • Florence Sonneville,
  • Manon Ruffin,
  • Christelle Coraux,
  • Nathalie Rousselet,
  • Philippe Le Rouzic,
  • Sabine Blouquit-Laye,
  • Harriet Corvol,
  • Olivier Tabary

DOI
https://doi.org/10.1038/s41467-017-00813-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.