Antondine Injection-Associated Fixed Drug Eruption: A Case Report

Abstract

Background: Fixed drug eruption (FDE) is a drug hypersensitivity reaction caused by antibiotics and non-steroidal anti-inflammatory drugs primarily. Antondine injection is a drug used to reduce fever, mainly composed of aminopyrine, antipyrine and barbiturate, and its adverse reactions include anaphylactic shock, epidermolysis, rash, agranulocytosis, etc. FDE caused by Antondine injection is an uncommon phenomenon, and the drug eruption caused by these ingredients has been reported in the current case report. However, the fatal severe fixed drug eruption caused by it has not been reported. Here, we report a case of severe PDE after treatment with Antondine, highlighting it’s necessary to avoid these medications with this ingredient when using antipyretic medications.