1,2-Oxidative Trifluoromethylation of Olefin with Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) and O<sub>2</sub>: Synthesis of α-Trifluoromethyl Ketones
Shengxue Zhang,
Wangchuan Xiao,
Jingjing Wu,
Fanhong Wu,
Houjin Huang,
Xiaoyu Ma,
Yafei Shi,
Chao Liu
Affiliations
Shengxue Zhang
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Wangchuan Xiao
Shanghai-Sanming Engineering Research Center of Green Fluoropharmaceutical Technology, 25 Jingdong Road, Sanming 365004, China
Jingjing Wu
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Fanhong Wu
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Houjin Huang
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Xiaoyu Ma
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Yafei Shi
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
Chao Liu
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O2CCF2SO2F) as a trifluoromethyl source is described with O2 as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
