Hemorheological system in coronary heart disease patients: prognostic value

Abstract

Aim. To develop highly sensitive prognostic methods for coronary heart disease (CHD) and acute coronary event (ACE) risk stratification, on the basis of biophysical hemorheological system assessment. Material and methods. Seven-year follow-up data on CHD patients were analyzed: re-hospitalization rate and reasons; main hemorheological parameters, their temporal and velocity characteristics; hemorheological system modeling by creating phase fragments in multi-dimensional phase space. Results. Whole blood viscosity was significantly higher in patients with 3 or more ACE, comparing to ACE-free individuals or participants with <3 ACE. Velocity parameter dynamics correlated with ACE hospitalization rate. Phase fragment method demonstrated hemorheological system destabilization, maximal in patients with 3 or more ACE. Conclusion. Prognostic value of whole blood viscosity and velocity assessment was demonstrated in CHD patients. Various CHD therapy algorithms, depending on hemorheological parameters and ACE risk, were developed.

Keywords

• coronary heart disease
• hemorheology
• acute coronary event
• prognosis