Nature Communications (Mar 2022)
Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis
- Shujie Chen,,
- Lu Zhang,
- Mengjie Li,
- Ying Zhang,
- Meng Sun,
- Lingfang Wang,
- Jiebo Lin,
- Yun Cui,
- Qian Chen,
- Chenqi Jin,
- Xiang Li,
- Boya Wang,
- Hao Chen,
- Tianhua Zhou,
- Liangjing Wang,
- Chih-Hung Hsu,
- Wei Zhuo
Affiliations
- Shujie Chen,
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Lu Zhang
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Mengjie Li
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Ying Zhang
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Meng Sun
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Lingfang Wang
- Women’s Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine
- Jiebo Lin
- Women’s Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine
- Yun Cui
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Qian Chen
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Chenqi Jin
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xiang Li
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Boya Wang
- Institute of Gastroenterology, Zhejiang University
- Hao Chen
- School of Medicine, Southern University of Science and Technology
- Tianhua Zhou
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Liangjing Wang
- Institute of Gastroenterology, Zhejiang University
- Chih-Hung Hsu
- Women’s Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine
- Wei Zhuo
- Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-28913-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Fusobacterium nucleatum contributes to host epitranscriptomic modifications and colorectal cancer (CRC) development. Here, the authors show that Fusobacterium nucleatum reduces global m6A modifications to promote CRC metastasis through a YAP/FOXD3/METTL3/KIF26B axis.
