CHIMIA (Apr 2003)

From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

  • Erwin Goetschi,
  • Fabienne Ricklin,
  • Peter Reindl,
  • Raffaello Masciadri,
  • Thomas Luebbers,
  • Helmut Link,
  • Dirk Kostrewa,
  • Paul Hebeisen,
  • Hans Gmuender,
  • Peter Angehrn,
  • Frank-Peter Theil

DOI
https://doi.org/10.2533/000942903777679505
Journal volume & issue
Vol. 57, no. 4

Abstract

Read online

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.

Keywords