The Relationship Between Serum Calcidiol Deficiency and The Degree of Sarcopenia in Elderly Communities in Surabaya

Abstract

Introduction. Calcidiol is a vitamin D metabolite used to determine vitamin D status. Calcidiol is the main form in circulation with a half-life of 2 to 3 weeks. In Indonesia, research on the relationship between serum calcidiol levels to the severity of sarcopenia has not yet been obtained. The purpose of this study was to analyze the relationship between serum calcidiol deficiency and the degree of sarcopenia in elderly communities in Surabaya. Method. This study was an observational analytic using cross-sectional design. Subjects were elderly who attended one of the five selected Posyandu during March - April 2019, who met the inclusion and exclusion criteria. Sarcopenia was diagnosed using muscle mass measurements evaluated using bio-impedance analysis (BIA), hand grip strength was measured with a handgrip dynamometer. Meanwhile, physical performance was assessed by gait speed. Calcidiol serum levels were measured using electrochemiluminescence immunoassay (ECLIA). Comparison tests were performed using chi square test (BxK) by merging cells between the deficiency and insufficiency groups. Results. Among total of 104 subjects, 52.9% of them was female elderly. The median age was 66.4 (60-82) years. We found calcidiol deficiency in 55.8% subjects, while the rest was non-deficient. Analytical test results showed a significant difference in serum calcidol levels between various degrees of sarcopenia (p = 0.03). Conclusion. There is a significant difference between serum calcidiol levels and the severity of sarcopenia in the elderly community.

Keywords

• calcidiol serum level
• community
• sarcopenia