Integrated microfluidic devices for in vitro diagnostics at point of care
Dan Liu,
Ying Wang,
Xingrui Li,
Mengmeng Li,
Qiaoyi Wu,
Yanling Song,
Zhi Zhu,
Chaoyong Yang
Affiliations
Dan Liu
Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities Key Laboratory of Xiamen Marine and Gene Drugs School of Biomedical Sciences Huaqiao University Fujian China
Ying Wang
Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities Key Laboratory of Xiamen Marine and Gene Drugs School of Biomedical Sciences Huaqiao University Fujian China
Xingrui Li
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and Technology Xinjiang University Urumqi China
Mengmeng Li
Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities Key Laboratory of Xiamen Marine and Gene Drugs School of Biomedical Sciences Huaqiao University Fujian China
Qiaoyi Wu
The Department of Emergency Surgery The First Affiliated Hospital of Fujian Medical University Fujian China
Yanling Song
The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Fujian China
Zhi Zhu
The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Fujian China
Chaoyong Yang
The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Fujian China
Abstract Given the continuous and growing demand for point of care (POC) diagnostic tests, attention has been shifted toward integration and miniaturization of laboratory protocols into “sample‐in‐answer‐out” devices. Microfluidic technologies have been considered an ideal solution to address the requirements of POC diagnostics since many laboratory functions can be miniaturized and incorporated onto a single integrated chip. In this review, we summarize the advances of integrated microfluidic devices for POC diagnostics in the last 3 years. Particularly, we summarize current materials used for microfluidic chip fabrication, discuss the innovation of versatile integrated microfluidic devices, especially the strategies for simplifying sample preparation in manual or self‐driven systems, and new detection methods of microfluidic chips. In addition, we describe new integrated microfluidic devices for POC diagnostics of protein‐targeted immunodiagnostics, nucleic acid molecular tests, and small molecule metabolites analysis. We also provide future perspectives and current challenges for clinical translation and commercialization of these microfluidic technologies.
