Nature Communications (Nov 2019)

Mapping the perturbome network of cellular perturbations

  • Michael Caldera,
  • Felix Müller,
  • Isabel Kaltenbrunner,
  • Marco P. Licciardello,
  • Charles-Hugues Lardeau,
  • Stefan Kubicek,
  • Jörg Menche

DOI
https://doi.org/10.1038/s41467-019-13058-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Our understanding of the mechanisms of drug interactions remains limited. Here the authors introduce a framework to study how complex cellular perturbations induced by different drugs affect each other in morphological feature space.