Nature Communications (Jun 2021)
Viral infiltration of pancreatic islets in patients with COVID-19
- Charlotte Steenblock,
- Stefanie Richter,
- Ilona Berger,
- Marko Barovic,
- Janine Schmid,
- Undine Schubert,
- Natalia Jarzebska,
- Anne von Mässenhausen,
- Andreas Linkermann,
- Annette Schürmann,
- Jessica Pablik,
- Thomas Dienemann,
- Katja Evert,
- Roman N. Rodionov,
- Natalia Y. Semenova,
- Vsevolod A. Zinserling,
- Raul R. Gainetdinov,
- Gustavo Baretton,
- Dirk Lindemann,
- Michele Solimena,
- Barbara Ludwig,
- Stefan R. Bornstein
Affiliations
- Charlotte Steenblock
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Stefanie Richter
- Institute of Virology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden
- Ilona Berger
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Marko Barovic
- Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus, Technische Universität Dresden
- Janine Schmid
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Undine Schubert
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Natalia Jarzebska
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Anne von Mässenhausen
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Andreas Linkermann
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Annette Schürmann
- Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus, Technische Universität Dresden
- Jessica Pablik
- Department of Pathology, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Thomas Dienemann
- Department of Surgery, University of Regensburg
- Katja Evert
- Institute of Pathology, University of Regensburg
- Roman N. Rodionov
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Natalia Y. Semenova
- S. P. Botkin Clinical Infectious Diseases Hospital
- Vsevolod A. Zinserling
- S. P. Botkin Clinical Infectious Diseases Hospital
- Raul R. Gainetdinov
- Institute of Translational Biomedicine, St. Petersburg State University
- Gustavo Baretton
- Department of Pathology, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Dirk Lindemann
- Institute of Virology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden
- Michele Solimena
- Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus, Technische Universität Dresden
- Barbara Ludwig
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Stefan R. Bornstein
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s41467-021-23886-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
New-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients, however, the underlying mechanisms are not fully understood. Here, the authors show that SARS-CoV-2 is detectable in both endocrine and exocrine cells of the pancreata of patients with COVID-19.
