Nature Communications (Jul 2018)
Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
- Axel Weber,
- Sigrid C. Schwarz,
- Jörg Tost,
- Dietrich Trümbach,
- Pia Winter,
- Florence Busato,
- Pawel Tacik,
- Anita C. Windhorst,
- Maud Fagny,
- Thomas Arzberger,
- Catriona McLean,
- John C. van Swieten,
- Johannes Schwarz,
- Daniela Vogt Weisenhorn,
- Wolfgang Wurst,
- Till Adhikary,
- Dennis W. Dickson,
- Günter U. Höglinger,
- Ulrich Müller
Affiliations
- Axel Weber
- Institute of Human Genetics, Justus-Liebig-Universität
- Sigrid C. Schwarz
- Department of Neurology, Technische Universität München
- Jörg Tost
- Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA—Institut de Biologie Francois Jacob
- Dietrich Trümbach
- Institute of Developmental Genetics, Helmholtz Center München
- Pia Winter
- Institute of Human Genetics, Justus-Liebig-Universität
- Florence Busato
- Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA—Institut de Biologie Francois Jacob
- Pawel Tacik
- Department of Neuroscience, Mayo Clinic
- Anita C. Windhorst
- Institute of Medical Informatics, Justus-Liebig-Universität
- Maud Fagny
- Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA—Institut de Biologie Francois Jacob
- Thomas Arzberger
- German Center for Neurodegenerative Diseases (DZNE)
- Catriona McLean
- Alfred Anatomical Pathology and NNF, Victorian Brain Bank
- John C. van Swieten
- Department of Neurology, Erasmus Medical Centre
- Johannes Schwarz
- Department of Neurology, Technische Universität München
- Daniela Vogt Weisenhorn
- German Center for Neurodegenerative Diseases (DZNE)
- Wolfgang Wurst
- German Center for Neurodegenerative Diseases (DZNE)
- Till Adhikary
- Institute for Molecular Biology and Tumor Research, Center for Tumor Biology and Immunology, Philipps University
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Günter U. Höglinger
- Department of Neurology, Technische Universität München
- Ulrich Müller
- Institute of Human Genetics, Justus-Liebig-Universität
- DOI
- https://doi.org/10.1038/s41467-018-05325-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression.
