DIAGNOSTIC AUTO-ANTIBODIES APPEAR MANY YEARS BEFORE SYMPTOM ONSET IN LYMPHOMA-PRONE SJOGREN’S SYNDROME (ВОЗМОЖНОСТЬ РАННЕЙ ДИАГНОСТИКИ СИНДРОМА ШЕГРЕНА КАК ПРЕДШЕСТВЕННИКА ЛИМФОМЫ НА ОСНОВЕ АУТОАНТИТЕЛ)

Abstract

Sjogren’s syndrome (SS) is a non-hereditary and relatively common disease with adult onset. It is characterized by extreme tiredness, diminished exocrine glandular function, specific auto-antibody production and focal infiltration of B and T lymphocytes. The disease may be also complicated by malignant lymphoma. Most SS patients have high serum levels of anti-nuclear antibodies (ANA), and the ANA subtypes SS-A and SS-B (autoantibodies to RNA-modifying spliceosome components) are used as diagnostic markers of SS. Antibodies to chromatin make cancer cells more sensitive to DNA-binding cytostatic drugs suggests that indeed the ANA in SS may have some influence on cellular functions, and perhaps contribute to SS patients’ symptoms.A most recent report from our department has demonstrated that ANA including SS-A and SS-B are present at high titres in sera obtained from SS patients many years before the onset of symptoms, and even longer times before the diagnosis was established.

Keywords

• синдром шегрена
• злокачественная лимфома
• антиядерные антитела
• днк