Identification of Long Non-Coding RNA SNHG Family as Promising Prognostic Biomarkers in Acute Myeloid Leukemia

Abstract

Jian Shi,1,* Weifeng Ding,2,* Hong Lu3 1Enzymology Laboratory, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic of China; 2Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic of China; 3Eye Institute, Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong LuEye Institute, Department of Ophthalmology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, People’s Republic of ChinaEmail [email protected]: Small nucleolar RNA host gene (SNHG) family members are newly recognized lncRNAs, which have been revealed to be oncogenes in several cancers. However, little studies investigated the expression and clinical implications of SNHGs in AML.Methods: Herein, we systemically determined the prognostic role of the expression of SNHG family members in acute myeloid leukemia (AML).Results: Among the expression of all SNHG family members, we identified that only SNHG7 and SNHG12 expression were found to have prognostic effects on overall survival (OS) and leukemia-free survival (LFS) in AML by Cox regression univariate analysis. Furthermore, Kaplan–Meier analysis showed that SNHG7 higher-expressed cases had markedly longer OS and LFS time than SNHG7 lower-expressed cases, whereas SNHG12 higher-expressed cases had markedly shorter OS and LFS time than SNHG12 lower-expressed cases. Interestingly, SNHG7 and SNHG12 expression were also associated with several prognosis-related clinical/molecular features such as white blood cell counts, FAB/cytogenetic classifications, IDH1 mutation, RUNX1 mutation, and NPM1 mutation. Despite the associations, Cox regression multivariate analysis confirmed the independent prognostic impact of SNHG7 and SNHG12 expression in AML. Notably, we further validated that both SNHG7 and SNHG12 expression was significantly increased in newly diagnosed AML patients.Conclusion: Our findings demonstrated that SNHG7 and SNHG12 expression act as independent prognostic indicators in AML.Keywords: LncRNA, SNHG, expression, prognosis, AML

Keywords

• lncrna
• snhg
• expression
• prognosis
• aml.