Prevalence of Streptococcus pneumoniae serotypes causing pneumococcal diseases in the Chinese Mainland: A systematic review and meta-analysis

Abstract

Pneumococcal disease (PD) caused by Streptococcus pneumoniae (Sp) continues to be a global public health concern. Monitoring the prevalence and shift of Sp serotypes causing PD is critical for vaccination and local policies for PD management. A systematic review of published work on pneumococcal serotype distribution in the Chinese Mainland from January 1997 to July 2023 was conducted. The literature was searched in Medline, Embase, the Cochrane Library, Web of Science, CNKI, and Wanfang. Distribution of the Sp serogroups/serotypes was presented as count and proportion. Pooled distributions were calculated using a double arcsine transformation. Subgroup analyses were performed according to isolate location, strain source, patient age, period, and clinical manifestation. In total 36,477 Sp isolates in 159 studies were included. In the Chinese Mainland, the highest proportion of Sp in PD was serotype 19F, followed by 19A, 23F, 14 and 6B. Serotype 19F was the most predominant circulating serotype through all time periods. PD cases caused by non-vaccine serotypes showed a significant increase after 2019. In summary, from 1997 to 2023, the top 10 prevalent Sp serotypes causing PD in the Chinese Mainland were 19F, 19A, 6, 23F, 14, 6B, 6A, 3, 15B, and 9 V. Although the distribution of serotypes varied according to the subgroups, the increase in non-vaccine serotypes (e.g. 15A), and diversity distribution of serotypes 6A and 3 in different age groups should not be ignored.

Keywords

• Streptococcus pneumoniae
• pneumococcal disease
• serotype
• systematic review
• meta-analysis