Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants

Zongyu Gao; Dingliang Zhang; Xiaoling Wang; Xin Zhang; Zhiyan Wen; Qianshen Zhang; Dawei Li; Savithramma P. Dinesh-Kumar; Yongliang Zhang

doi:10.1038/s41467-022-28395-5

Nature Communications (Feb 2022)

Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants

Zongyu Gao,
Dingliang Zhang,
Xiaoling Wang,
Xin Zhang,
Zhiyan Wen,
Qianshen Zhang,
Dawei Li,
Savithramma P. Dinesh-Kumar,
Yongliang Zhang

Affiliations

Zongyu Gao: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Dingliang Zhang: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Xiaoling Wang: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Xin Zhang: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Zhiyan Wen: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Qianshen Zhang: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Dawei Li: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Savithramma P. Dinesh-Kumar: Department of Plant Biology and The Genome Center, College of Biological Sciences, University of California, Davis
Yongliang Zhang: State Key Laboratory of Agro-Biotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University

DOI: https://doi.org/10.1038/s41467-022-28395-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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MAPK cascades play an important role in innate immunity. Here, the authors show that that beet black scorch virus activates MAPK signaling in Nicotiana benthamiana and the viral coat protein counteracts MAPK-mediated defence by competitively binding to a MAPKKKα interactor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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