Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Eugenia Zah; Eunwoo Nam; Vinya Bhuvan; Uyen Tran; Brenda Y. Ji; Stanley B. Gosliner; Xiuli Wang; Christine E. Brown; Yvonne Y. Chen

doi:10.1038/s41467-020-16160-5

Nature Communications (May 2020)

Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Eugenia Zah,
Eunwoo Nam,
Vinya Bhuvan,
Uyen Tran,
Brenda Y. Ji,
Stanley B. Gosliner,
Xiuli Wang,
Christine E. Brown,
Yvonne Y. Chen

Affiliations

Eugenia Zah: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles
Eunwoo Nam: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles
Vinya Bhuvan: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles
Uyen Tran: Department of Chemistry and Biochemistry, University of California–Los Angeles
Brenda Y. Ji: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles
Stanley B. Gosliner: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles
Xiuli Wang: Department of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratory, City of Hope Beckman Research Institute and Medical Center
Christine E. Brown: Department of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratory, City of Hope Beckman Research Institute and Medical Center
Yvonne Y. Chen: Department of Chemical and Biomolecular Engineering, University of California–Los Angeles

DOI: https://doi.org/10.1038/s41467-020-16160-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associated antigens and demonstrate its superiority to single-antigen CARs in a mouse model of MM.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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