Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores

Abstract

Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).

Keywords

• tetraoxanes
• 4-aminoquinolines
• malaria
• P. falciparum