Nature Communications (Mar 2023)
Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans
- Kodihalli C. Ravindra,
- Vishal S. Vaidya,
- Zhenyu Wang,
- Joel D. Federspiel,
- Richard Virgen-Slane,
- Robert A. Everley,
- Jane I. Grove,
- Camilla Stephens,
- Mireia F. Ocana,
- Mercedes Robles-Díaz,
- M. Isabel Lucena,
- Raul J. Andrade,
- Edmond Atallah,
- Alexander L. Gerbes,
- Sabine Weber,
- Helena Cortez-Pinto,
- Andrew J. Fowell,
- Hyder Hussaini,
- Einar S. Bjornsson,
- Janisha Patel,
- Guido Stirnimann,
- Sumita Verma,
- Ahmed M. Elsharkawy,
- William J. H. Griffiths,
- Craig Hyde,
- James W. Dear,
- Guruprasad P. Aithal,
- Shashi K. Ramaiah
Affiliations
- Kodihalli C. Ravindra
- Worldwide Research Development and Medical
- Vishal S. Vaidya
- Worldwide Research Development and Medical
- Zhenyu Wang
- Worldwide Research Development and Medical
- Joel D. Federspiel
- Worldwide Research Development and Medical
- Richard Virgen-Slane
- Worldwide Research Development and Medical
- Robert A. Everley
- Worldwide Research Development and Medical
- Jane I. Grove
- NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham
- Camilla Stephens
- Servicios de Aparato Digestivo y Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA Plataforma Bionand, Hospital Universitario Virgen de la Victoria, Universidad de Málaga
- Mireia F. Ocana
- Worldwide Research Development and Medical
- Mercedes Robles-Díaz
- Servicios de Aparato Digestivo y Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA Plataforma Bionand, Hospital Universitario Virgen de la Victoria, Universidad de Málaga
- M. Isabel Lucena
- Servicios de Aparato Digestivo y Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA Plataforma Bionand, Hospital Universitario Virgen de la Victoria, Universidad de Málaga
- Raul J. Andrade
- Servicios de Aparato Digestivo y Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA Plataforma Bionand, Hospital Universitario Virgen de la Victoria, Universidad de Málaga
- Edmond Atallah
- NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham
- Alexander L. Gerbes
- Department of Medicine II, University Hospital
- Sabine Weber
- Department of Medicine II, University Hospital
- Helena Cortez-Pinto
- Clínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa
- Andrew J. Fowell
- Department of Gastroenterology and Hepatology, Portsmouth Hospitals University NHS Trust
- Hyder Hussaini
- Department of Gastroenterology and Hepatology, Royal Cornwall Hospitals NHS Trust
- Einar S. Bjornsson
- Department of Gastroenterology, Landspitali University Hospital Reykjavik
- Janisha Patel
- University Hospital Southampton
- Guido Stirnimann
- University Clinic for Visceral Surgery and Medicine, University Hospital Inselspital and University of Bern
- Sumita Verma
- Brighton and Sussex Medical School and University Hospitals Sussex NHS Foundation Trust
- Ahmed M. Elsharkawy
- Liver Unit and NIHR Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital
- William J. H. Griffiths
- Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust
- Craig Hyde
- Worldwide Research Development and Medical
- James W. Dear
- Pharmacology, Therapeutics and Toxicology, Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute
- Guruprasad P. Aithal
- NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham
- Shashi K. Ramaiah
- Worldwide Research Development and Medical
- DOI
- https://doi.org/10.1038/s41467-023-36858-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distinguish it from alternative causes of liver injury.
