Frontiers in Pharmacology (Nov 2020)
Roles of Hydrogen Sulfide Donors in Common Kidney Diseases
- Ebenezeri Erasto Ngowi,
- Ebenezeri Erasto Ngowi,
- Ebenezeri Erasto Ngowi,
- Muhammad Sarfraz,
- Muhammad Sarfraz,
- Muhammad Sarfraz,
- Muhammad Sarfraz,
- Attia Afzal,
- Attia Afzal,
- Attia Afzal,
- Nazeer Hussain Khan,
- Nazeer Hussain Khan,
- Saadullah Khattak,
- Saadullah Khattak,
- Xin Zhang,
- Xin Zhang,
- Tao Li,
- Tao Li,
- Shao-Feng Duan,
- Shao-Feng Duan,
- Shao-Feng Duan,
- Xin-Ying Ji,
- Xin-Ying Ji,
- Xin-Ying Ji,
- Dong-Dong Wu,
- Dong-Dong Wu,
- Dong-Dong Wu
Affiliations
- Ebenezeri Erasto Ngowi
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Ebenezeri Erasto Ngowi
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Ebenezeri Erasto Ngowi
- Department of Biological Sciences, Faculty of Science, Dar es Salaam University College of Education, Dar es Salaam, Tanzania
- Muhammad Sarfraz
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Muhammad Sarfraz
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Muhammad Sarfraz
- Kaifeng Municipal Key Laboratory of Cell Signal Transduction, Henan Provincial Engineering Centre for Tumor Molecular Medicine, Henan University, Kaifeng, China
- Muhammad Sarfraz
- Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan
- Attia Afzal
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Attia Afzal
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Attia Afzal
- Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan
- Nazeer Hussain Khan
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Nazeer Hussain Khan
- College of Pharmacy, Henan University, Kaifeng, China
- Saadullah Khattak
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Saadullah Khattak
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Xin Zhang
- College of Pharmacy, Henan University, Kaifeng, China
- Xin Zhang
- Institute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, Kaifeng, China
- Tao Li
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Tao Li
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Shao-Feng Duan
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Shao-Feng Duan
- College of Pharmacy, Henan University, Kaifeng, China
- Shao-Feng Duan
- Institute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, Kaifeng, China
- Xin-Ying Ji
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Xin-Ying Ji
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Xin-Ying Ji
- Diseases and Bio-Safety, School of Basic Medical Sciences, Henan University, Kaifeng, China
- Dong-Dong Wu
- School of Basic Medical Sciences, Henan University, Kaifeng, China
- Dong-Dong Wu
- Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, China
- Dong-Dong Wu
- School of Stomatology, Henan University, Kaifeng, China
- DOI
- https://doi.org/10.3389/fphar.2020.564281
- Journal volume & issue
-
Vol. 11
Abstract
Hydrogen sulfide (H2S) plays a key role in the regulation of physiological processes in mammals. The decline in H2S level has been reported in numerous renal disorders. In animal models of renal disorders, treatment with H2S donors could restore H2S levels and improve renal functions. H2S donors suppress renal dysfunction by regulating autophagy, apoptosis, oxidative stress, and inflammation through multiple signaling pathways, such as TRL4/NLRP3, AMP-activated protein kinase/mammalian target of rapamycin, transforming growth factor-β1/Smad3, extracellular signal-regulated protein kinases 1/2, mitogen-activated protein kinase, and nuclear factor kappa B. In this review, we summarize recent developments in the effects of H2S donors on the treatment of common renal diseases, including acute/chronic kidney disease, renal fibrosis, unilateral ureteral obstruction, glomerulosclerosis, diabetic nephropathy, hyperhomocysteinemia, drug-induced nephrotoxicity, metal-induced nephrotoxicity, and urolithiasis. Novel H2S donors can be designed and applied in the treatment of common renal diseases.
Keywords
