Nature Communications (Jan 2021)
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
- Cheolmin Kim,
- Dong-Kyun Ryu,
- Jihun Lee,
- Young-Il Kim,
- Ji-Min Seo,
- Yeon-Gil Kim,
- Jae-Hee Jeong,
- Minsoo Kim,
- Jong-In Kim,
- Pankyeom Kim,
- Jin Soo Bae,
- Eun Yeong Shim,
- Min Seob Lee,
- Man Su Kim,
- Hanmi Noh,
- Geun-Soo Park,
- Jae Sang Park,
- Dain Son,
- Yongjin An,
- Jeong No Lee,
- Ki-Sung Kwon,
- Joo-Yeon Lee,
- Hansaem Lee,
- Jeong-Sun Yang,
- Kyung-Chang Kim,
- Sung Soon Kim,
- Hye-Min Woo,
- Jun-Won Kim,
- Man-Seong Park,
- Kwang-Min Yu,
- Se-Mi Kim,
- Eun-Ha Kim,
- Su-Jin Park,
- Seong Tae Jeong,
- Chi Ho Yu,
- Youngjo Song,
- Se Hun Gu,
- Hanseul Oh,
- Bon-Sang Koo,
- Jung Joo Hong,
- Choong-Min Ryu,
- Wan Beom Park,
- Myoung-don Oh,
- Young Ki Choi,
- Soo-Young Lee
Affiliations
- Cheolmin Kim
- Biotechnology Research Institute, Celltrion Inc
- Dong-Kyun Ryu
- Biotechnology Research Institute, Celltrion Inc
- Jihun Lee
- Biotechnology Research Institute, Celltrion Inc
- Young-Il Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Ji-Min Seo
- Biotechnology Research Institute, Celltrion Inc
- Yeon-Gil Kim
- Pohang Accelerator Laboratory, Pohang University of Science and Technology
- Jae-Hee Jeong
- Pohang Accelerator Laboratory, Pohang University of Science and Technology
- Minsoo Kim
- Biotechnology Research Institute, Celltrion Inc
- Jong-In Kim
- Biotechnology Research Institute, Celltrion Inc
- Pankyeom Kim
- Biotechnology Research Institute, Celltrion Inc
- Jin Soo Bae
- Biotechnology Research Institute, Celltrion Inc
- Eun Yeong Shim
- Biotechnology Research Institute, Celltrion Inc
- Min Seob Lee
- Biotechnology Research Institute, Celltrion Inc
- Man Su Kim
- Biotechnology Research Institute, Celltrion Inc
- Hanmi Noh
- Biotechnology Research Institute, Celltrion Inc
- Geun-Soo Park
- Biotechnology Research Institute, Celltrion Inc
- Jae Sang Park
- Biotechnology Research Institute, Celltrion Inc
- Dain Son
- Biotechnology Research Institute, Celltrion Inc
- Yongjin An
- Biotechnology Research Institute, Celltrion Inc
- Jeong No Lee
- Biotechnology Research Institute, Celltrion Inc
- Ki-Sung Kwon
- Biotechnology Research Institute, Celltrion Inc
- Joo-Yeon Lee
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Hansaem Lee
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Jeong-Sun Yang
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Kyung-Chang Kim
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Sung Soon Kim
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Hye-Min Woo
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Jun-Won Kim
- Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention
- Man-Seong Park
- Department of Microbiology and Institute for Viral Diseases, College of Medicine, Korea University
- Kwang-Min Yu
- College of Medicine and Medical Research Institute, Chungbuk National University
- Se-Mi Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Eun-Ha Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Su-Jin Park
- College of Medicine and Medical Research Institute, Chungbuk National University
- Seong Tae Jeong
- The 4th R&D Institute, Agency for Defense Development
- Chi Ho Yu
- The 4th R&D Institute, Agency for Defense Development
- Youngjo Song
- The 4th R&D Institute, Agency for Defense Development
- Se Hun Gu
- The 4th R&D Institute, Agency for Defense Development
- Hanseul Oh
- National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology
- Bon-Sang Koo
- National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology
- Jung Joo Hong
- National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology
- Choong-Min Ryu
- Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology
- Wan Beom Park
- Department of Internal Medicine, Seoul National University College of Medicine
- Myoung-don Oh
- Department of Internal Medicine, Seoul National University College of Medicine
- Young Ki Choi
- College of Medicine and Medical Research Institute, Chungbuk National University
- Soo-Young Lee
- Biotechnology Research Institute, Celltrion Inc
- DOI
- https://doi.org/10.1038/s41467-020-20602-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models.
